Because somewhere over her entire life, alter-Ione would, at some point, have done that, and remembered it, even if she was sad about it.  So she wouldn't say that to Keltham because it would be a lie -

Ione, stop this, this is NOT THE ALTER-VERSION of our conversation, that's an order.

Alter-Asmodia says that she sure wants us to both end up Cooperating, but no matter what kind of conversation we have about that, she doesn't see why we wouldn't just both Defect.

Because somewhere over her entire life, alter-Ione would, at some point, have hurt someone innocent, and remembered it, even if she was sad about it.  So she wouldn't say that to Keltham because it would be a lie -

Ione, stop this, this is NOT THE ALTER-VERSION of our conversation, that's an order.

Alter-Asmodia says that she sure wants us to both end up Cooperating, but no matter what kind of conversation we have about that, she doesn't see why we wouldn't just both Defect.